Research in the Mertz group uses computational and experimental methods to study membrane proteins, with an emphasis on:
- design of membrane scaffolds for bacterial proton pumps
- characterization and design of membrane insertion peptides
- drug development
- optimization of bioelectronic circuits
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Bacterial proton pumps and alternative energy:
Proteorhodopsin (PR) is a recently discovered membrane protein that acts as the light-activated proton pump, driving chemical energy synthesis in many marine bacteria. Our lab is focused on fundamental understanding of this process by simulating PR on the molecular level using molecular dynamics, as well as investigating the potential for using PR arrays in alternative energy devices for the purpose of solar-to-chemical energy conversion. You can read more about our work on PR here, here, here, and here. |
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Rational design of membrane insertion peptides:
Anionic peptides have been shown to undergo spontaneous coil-to-helix transition and subsequent unidirectional insertion in an acidic cellular microenvironment, making them ideal for targeted drug delivery to cancer cells. Our lab is modeling the membrane insertion process of these peptides in order to understand their structure-function relationship with respect to membrane environment. Long-term, this research will lead to the ability to improve targeted specificity of these peptides. You can read more about our work here, here, and here.
Anionic peptides have been shown to undergo spontaneous coil-to-helix transition and subsequent unidirectional insertion in an acidic cellular microenvironment, making them ideal for targeted drug delivery to cancer cells. Our lab is modeling the membrane insertion process of these peptides in order to understand their structure-function relationship with respect to membrane environment. Long-term, this research will lead to the ability to improve targeted specificity of these peptides. You can read more about our work here, here, and here.
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Optimization of bioelectronic circuits:
Proteins are able to conduct electricity when incorporated into a solid-state junction, but the relationship between protein structure and the pathway of electron transport remains unclear. Our lab is carrying out transport calculations to identify the pathway of electrons through peptides that are incorporated into circuits. This knowledge will lead to fundamental understanding of this phenomena and improvement of bioelectronics design. You can read more about our work here.
Proteins are able to conduct electricity when incorporated into a solid-state junction, but the relationship between protein structure and the pathway of electron transport remains unclear. Our lab is carrying out transport calculations to identify the pathway of electrons through peptides that are incorporated into circuits. This knowledge will lead to fundamental understanding of this phenomena and improvement of bioelectronics design. You can read more about our work here.
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Chemistry Research Laboratory Room 285
The C. Eugene Bennett Department of Chemistry
West Virginia University
Morgantown, WV 26506
The C. Eugene Bennett Department of Chemistry
West Virginia University
Morgantown, WV 26506
